Nippon Rika's motto is 'Customer First.'
We are committed to providing the highest quality and service.
Since its founding, Nippon Rika Co., Ltd. has focused on amino acids, the source of life, and was a pioneer in amino acid manufacturing. Since then, we have supplied high-quality amino acids to countries around the world for use in pharmaceuticals, food, and cosmetics. Based on the properties of amino acids, we not only provide raw materials but also explore the infinite possibilities that lie beyond amino acids.
Our Strengths
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Integrated Production System
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Established
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Global Support
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Electrolysis Technology
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High-Purity Purification
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Jet Mill Grinding
Plant Specifications
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Plant Area
33,000m²
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+ Explosion-Proof
GMP Plant
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Total Reactor Capacity
82,000L
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Ashikaga Plant Staff
80
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Wastewater Treatment
400m³/day
Global Compliance
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ISO 14001 Certified Plant
National Drug Regulatory Authorities and Certification Bodies
PMDA (Pharmaceuticals and Medical Devices Agency, Japan)
FDA (U.S. Food and Drug Administration)
EDQM (European Directorate for Drug Quality)
NMPA (China National Medical Products Administration)
Ashikaga Plant
Our plant is located in Ashikaga City, in southern Tochigi Prefecture, a region with an ideal climate for production and convenient distribution. We boast world-class production volumes of pharmaceutical cysteine and its derivatives, as well as infusion-grade L-tyrosine. To consistently pursue stable quality, stable supply, and low costs, we are committed to improving our GMP* standards and establishing a world-class quality assurance system. Furthermore, we are ISO 14001 certified and are constantly striving to build factories that are environmentally, health, and safety-conscious.
Address: 610 Yanada-cho, Ashikaga City, Tochigi Prefecture, 326-0321;
Site Area: 37,000m²
R&D facilities and equipment
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Process Chemistry Lab
0.01-10L Glass Reactor
100g Scale Electrolysis Apparatus
Two Vacuum Shelf Dryers
Up to 2L/Up to 5L Rotary Evaporators
0.1L Pressure Filter
Up to 0.1L Organic Synthesis Apparatus
Two Small Centrifuges (for Crystal Separation)
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Kilo Lab
50L GL Reactor
Φ330mm Magnetic Nutsche
100L GL Reactor
Kilogram-Scale Prototype Electrolysis Apparatus
10L/20L Glass Filter Bottles
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Physical and Chemical Testing
Particle Size Distribution Analyzer
FT-IR
Karl Fischer Moisture Analyzer
TOC Analyzer
Headspace Sampler
UV-VIS Spectrophotometer
Whiteness Analyzer
Amino Acid Analyzer
HPLC
Kjeldahl Distillation Apparatus
Atomic Absorption Spectrophotometer
Automatic Titrator
Ion Meter
LC-MS
Automatic Melting Point Apparatus
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Microbiological Testing
Autoclave
Safety Cabinet
Dry Heat Sterilizer
Microplate Reader
Clean Bench
Toxinometer
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Others
Stability Tester
Jet Mill Grinders
High-speed jet airflow causes crystals to collide and pulverize. Since the temperature rise is minimal, it is also suitable for pulverizing heat-sensitive materials.
Electrolyzer
We have the technology to convert cystine to cysteine through electrolysis.
Pilot Plant
Commercial Production Capacity (As of October 1, 2025)
Core Technology
Contact us for contract manufacturing inquiries.
| Amino Acids (especially cysteine and tyrosine) |
Amino Group | Acetylation, Formylation, Cbz Derivatization, Boc Derivatization |
|---|---|---|
| Carboxyl Group | Esterification (methyl, ethyl, etc.), Reduction (alcohol conversion) | |
| Side Chain | Alkylation, Methylcarboxylation, Amidation | |
| Others/td> | Racemization Electrolytic reduction (cystine to cysteine) Electrolytic desalination (hydrochloride-free) High-purity purification (increased content, trace metal removal) |
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| Others | (Reactions) Esterification, amidation, acylation, sulfonation, NaBH4 reduction, acid chloride formation |
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Main Analytical Instruments
- Particle Size Distribution Analyzer
- Automatic Moisture Measurement System (Volumetric/Coulometric)
- Infrared Spectrophotometer (FT-IR)
- pH Meter
- UV-Visible Spectrophotometer
- Automatic Melting Point Analyzer
- Atomic Absorption Spectrometer
- Viscometer
- Total Organic Carbon Analyzer (TOC)
- High-Performance Liquid Chromatograph (HPLC)
- Laser Diffraction Particle Size Analyzer
- High-Performance Liquid Chromatograph + Photodiode Array Detector
- Thermogravimetric Analyzer (TG)
- High-Performance Liquid Chromatograph + Ion Trap Mass Spectrometer
- Gas Chromatograph (GC)
- Amino Acid Analyzer
- Polarimetry
- Gas Chromatograph + Headspace Sampler
- Refractometer
- Endotoxin Measurement System
- Automatic Potentiometric Titrator
